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Neurotechnology Industry 2009 Report

Yikes. The Neurotechnology Industry 2009 Report been out for months and I’m just now posting? Don’t let that be an excuse to not click and obtain immediately — or sooner, if already fully cog-chipped-up, of course. ;-)

Drugs, Devices and Diagnostics for the Brain and Nervous System: Market Analysis and Strategic Investment Guide of the Global Neurological Disease and Psychiatric Illness Markets

Now in its fifth year, The Neurotechnology Industry 2009 Report is an expanded and updated 480 page report of brain and nervous system markets and treatments. It is the only publication to provide a unified market-based framework to help investors, companies and entrepreneurs easily identify opportunities, understand the competitive landscape, determine risks and understand the dynamics of rapidly changing CNS markets.

Real Discrimination Against Digital People

And many other leading edge topics in this Summer Edition of H+ Magazine, now on news stands like this one everywhere.

I must have lost half of my potential contracts because the company wouldn’t deal with an anonymous avatar.

Why Digital People?

It was around 1999, about four of five years before I finally started this blog, and many of the topics covered herein were considered so fringe as to threaten my real employment, social credibility, and even mental health assessment. I had been discriminatorily profiled in the past as manifesting mental illness in the form of various overachieving cognition crimes, such as being comparatively well informed about relatively fringe science and technology progress, understanding which technologies are likely coming next, and for concisely (and in retrospect, fairly accurately) forecasting a number of likely uses and implications for those emerging capabilities. However, I do not consider myself a “futurist” in the science fiction sense; I tend rather to gravitate toward the interface between the potential and the actual; I naturally find myself studying, advocating for, participating in, or at the very least desiring to act as a catalyzing agent that helps in some small way to transmute the potential into the next new actual.

In some of those earlier cases, I’d helped to found companies that went on to build some everyday technologies that we now take for granted. At one point, I was literally told by investors and other well respected authoritative normals that I was not mentally well for pronouncing intentions that I went on to fulfill in every way. That particular technology’s trajectory is well documented and part of it even went on to include new IEEE standards.

What I learned from such experiences is that it is empirically dangerous to share some of my understandings and insights with humans that populate the center of the bell curve. That’s a lot of humans, friend. Some of them, in fact many of them, would have locked me up and medicated me rather permit me to go on and build technologies that you yourself are very likely using today, if you use the internet every single day.

So, I was forced to realize how the normals treat people who see things a little “too differently” from them; and from my perspective, such people became a very clear and present danger. I realized that I had to find ways to protect myself. Unsurprisingly, again in retrospect, that protection came in the form of surrounding myself with similar beings to the greatest degree possible; first by modem, then by academic association and increasing education, then by physical relocation to a part of the country where cognitive diversity was held a little less suspect.

In some cases, even that didn’t feel like enough. When I began understanding that brain computer interfaces and other posthuman eventualities were not just possible, but both inevitable and desirable, I was utterly closed-lipped about it in public. I knew that if I began talking about these things as if they were obvious, the normals would bound me, medicate me, and I would never be heard from again. Yet, I simply *had* to have an outlet for these ideas and other emerging trends that I perceived as directly or tangentially interdependent in the construction of our posthuman future.

At that time, I hadn’t yet heard of the word posthuman; but I fully understood and expected positive permutations of posthumanity to emerge within the subsequent 20, 50, and 100 years. We’re now 10 years into that first 20 year time frame. I also wanted to publish and broadcast such “fringe” thoughts in a way that might help others who viewed the world similarly to the way I perceived it, to feel emboldened, allied, encouraged, and motivated. Thus emerged the precursor to this site, A Webcam Darkly and later, as I began understanding this little experiment in accountable anonymity and technoprogressive futurtechture: Metavalent Stigmergy.

While the past decade has seen some gains in cognitive tolerance, we have a long, long way to go toward building a world that is safe and supportive of both physical and mental morphological diversity.

In today’s world, it’s fine if you have the cash and established social standing of a Ray Kurzweil or James Hughes to defend yourself; but there are thousands of us who share lesser or less developed and varied permutations of such forward-leaning cognitive styles, who do not yet possess such robust defense systems or even sufficiently fully architected personnas. Consequently, we are numbered among those who are expected to keep working at 7-11 or Kmart, or maybe manage a few other writers, or herd cats for some pointy-haired boss’s project or program; even as we see the world accelerating all around us in ways that create a more than full time autodidact vocation of simply keeping up, in hopes of preparing for, and adapting to whatever comes next. We live in a world where the normals won’t let us have money or eat or have a house if we don’t spend the majority of our already far-too-brief lives engaged in these relatively meaningless and mundane tasks that society understands as perpetuating its own safe status quo; yet, the overwhelming time and attention demands of that perceived safety effectively shackles our own intellectual, id est, existential puissance.

So this issue of H+ Magazine coincides with a bit of a personal watershed. The topics being discussed are now sufficiently well understood and have been experienced by a large enough constituency, that it is tempting to call the all clear and to feel safe coming out from both the real and perceived social safety of this dual purpose identity bunker and experiment in accountable anonymity. I’ve experimented over the past five years or so in creating an identity that is both relatively anonymous and yet fully accountable to the community in every way. I say relatively because it’s also relatively easy to put together the pieces and find my biological identity if you care; I just don’t flat out give people the easy answer, outside of a very close circle of friends. Second Life has helped tremendously to advance the cause of accountable anonymity, but the ultimate achievement would be to coexist in a world where we are all safe amongst the normals; where cognitive diversity is not just tolerated, but celebrated. Now I’m really dreaming, huh?

Toward that apparitional aspiration, perhaps we could create a magazine and sell the normals harmless pills with polysyllabic names that persuade them to believe that they too are exceptional, or at least that they too might have the potential to become exceptional. Or perhaps we could create television programs like The 4400 or Heroes that help to portray those deviant technoprogressive thinkers and positivistic posthuman dreamers as potential super allies. Nah, that’d never work. Humans aren’t that gullible.

Right.

Cortical Dynamics and Perception

Cortical Dynamics and Perception

Chris Moore
MIT
Monday 01st of June 2009 at 12:00pm
508-20 Evans Hall

Our laboratory studies how rapid changes in neural organization, on the time scale of milliseconds to seconds, shape perception. Our key model system is the primary somatosensory cortex (SI), with a strong emphasis on the vibrissa ‘barrel’ cortex. In human MEG studies of tactile detection, we have shown that dynamics in the SI evoked response predict detection (Jones et al., 2007). This seminar will focus on two mechanisms for regulating such dynamics. First, we will discuss our recent studies of the origins of the gamma rhythm in the neocortex, a rhythm believed crucial to a variety of cognitive abilities including selective attention. To test the hypothesis that synchrony of fast-spiking inhibitory interneurons (FS) is causal in gamma genesis, we employed cell-type specific transfection of mouse neocortex with Channelrhodopsin-2. We found that selective optical drive of FS induced the gamma rhythm, while selective drive of excitatory cells induced lower frequency rhythms, a cell type specific double-dissociation in state induction. We further showed that phase of the gamma rhythm regulates the whisker-driven SI evoked response on the time scale milliseconds (Cardin et al., 2009). Second, we will discuss a less conventional mechanism for regulating cortical dynamics, the ‘Hemo-Neural’ hypothesis (Moore and Cao, 2008). This hypothesis predicts that local changes in hemodynamics–such as the functional hyperemia underlying the BOLD fMRI signal–can modulate local neural excitability . I will describe new methods we have developed for the selective control of blood flow in the brain to test this hypothesis, and
our preliminary data showing cell-type specific modulation of SI evoked responses associated with local arterial dilation.

How many simulated advanced civilization gods can you fit on the tip of an atomic-scale scanning probe manipulator?

File under “previously considered highly unlikely sources” for transhumanist philosophical spelunking? On the other hand, as more and more religions attempt to assimilate transhumanist principles into their respective canons; that can only assist the transreligious cause of transhuman progress, no?

It’s true that if an advanced civilization could create a simulation indistinguishable from the natural universe, we very well may be in one. We may be brains in a jar, or batteries for robots. We can speculate about some meta-reality above our own, whether it be a computer program or an alternate dimension, but there’s no reason to think any of them might be true. Without any evidence, even if we are in a simulation, it’s more reasonable to assume that we aren’t.

Indeed, without any evidence, we can’t distinguish any of these possibilities. It may be that we are just feeding electrical energy into the robots that rule the planet. This isn’t any more or less likely than any other simulation (or creation story) we might suggest.

Picture of the day


Telegraph.co.uk: “If you have always wanted to be part of an integrated circuit board, Bare paint will make it possible. The special paint, created at the Royal College of Art, conducts electricity…” Picture: WENN

Everything I Ever Wanted to Know About Mindclones

… but was afraid to ask. By the ever erudite Martine Rothblatt:

A mindclone is a software version of your mind.  He or she is all of your thoughts, recollections, feelings, beliefs, attitudes and values, and is experiencing reality from the standpoint of whatever machine their mindware is running on.  Mindclones are mindfiles being used and updated by mindware that has been set to be a functionally equivalent replica of one’s mind.  A mindclone is your software-based alter ego, doppelganger, or mental twin.

Humanizing our Posthuman Near Future

We should welcome with open arms the rich possibilities of technologically enhancing our bodies,” reports Andy Miah in the Guardian this week, adding the important caveat, “just so long as we don’t all end up looking, and thinking, and acting the same.”

[Next month,] The European Parliament is set to debate issues surrounding smart drugs, cybernetic body enhancements, cosmetic surgery and more over the coming months to “establish an advisory committee on all aspects of human enhancement, the first committee of its kind.”

After all “we have always been beings in transition,” argues Miah, who think the key is to find ways to “support responsible use” of body modifying technologies.

“Legs-on” with Honda’s walking-assist devices



Cosmetic Neurology & Neuro Enhancers

Reprinted from NPR.org.

Listen to Fresh Air from WHYY, April 20, 2009· In the modern world of busy schedules and busier lives, some people are turning to “neuro-enhancing” drugs to gain a competitive edge.

Proponents of “cosmetic neurology” say that the drugs allow people to reach their full potential, while critics warn that the drugs have not been tested for off-label uses, and that some may be addictive or harmful.

Read: Brain Gain, by Margaret Talbot, The New Yorker. April 27, 2009.

How to Map Neural Circuits With an Electron Microscope

Coders and neuroscientists have teamed up to make a 20-terabyte map of every cell in the back of a rabbit’s eye. By comparing healthy samples with pictures of damaged retinas, these researchers can make sense of the diseases that cause blindness, and perhaps find ways to repair injured eyes.


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Way Too Much Information

meta-
adj.,pref. [from analytic philosophy] One level of description up. A metasyntactic variable is a variable in notation used to describe syntax, and meta-language is language used to describe language. This is difficult to explain briefly, but much hacker humor turns on deliberate confusion between meta-levels.

-valent
suff. Having a specified valence or valences.

valence
1. Chemistry. The combining capacity of an atom or radical, determined by the number of electrons that it will lose, add, or share when it reacts with other atoms.
2. The ability of a substance to interact with another or to produce an effect.
3. Psychology. The degree of attraction or aversion that an individual feels toward a specific object or event.
4. Linguistics. The number of arguments that a lexical item, especially a verb, can combine with to make a syntactically well-formed sentence, often along with a description of the categories of those constituents.
5. The capacity of something to unite, react, or interact with something else.

an extropic state
of contemplating supersymmetric psychosocial symphonies of
human suffering, surmounting, senescence, and survival through
an incomprehensibly vast and escalating expansion of the extropian multiverse. speculative spelunking through assymetric archipelagos of mechapsychogenetic transhuman permutation, pain and poise, pretense and probity, prevarication and promise.

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